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February 19, 2026The FASEB JournalOpen Access

Cobalt Chloride Protects Against Intestinal Irradiation‐Induced Injury by Activating the HIF ‐2α

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Authors

JZJianpeng ZhaoRLRuling LiuZSZhaoyong Shou

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Overview

Demonstrates cobalt chloride's protective effect on intestinal radiation injury, suggesting new radiation protection strategies.

Key Points

  • To explore the protective effects of cobalt chloride on intestinal radiation injury and its underlying mechanisms.
  • Systematic examination across cells, intestinal tissues, intestinal organoids, and live mice.
  • Assessment of radiation tolerance and injury scores in treated vs. untreated mice.
  • Evaluation of gene expression related to cell proliferation and barrier protection.
  • CoCl 2 pretreatment significantly improved survival rates and intestinal injury scores in mice.
  • Enhanced proliferation and differentiation of intestinal organoids were observed.
  • CoCl 2 inhibited apoptosis in intestinal epithelial cells and increased expression of protective genes.

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/6996a82decb39a600b3ee9b9https://doi.org/10.1096/fj.202501410r
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