ABSTRACT The C─O bond cleavage has always been a central challenge for deoxygenation due to high bond dissociation energies. Here, we develop a Lewis acid‐promoted polarity inversion strategy that enables a strong C─O bond cleavage and rapid access to nitriles from carbonyls. Its broad applicability, together with the nontoxic and mild conditions, underscores the highly modular nature of this method.
Meng et al. (Tue,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: