Ingestion of Bifidobacterium longum subspecies infantis strain CCFM687 regulated emotional behavior and the central BDNF pathway in chronic stress-induced depressive mice through reshaping the gut microbiota

Puntos clave

• The research aims to explore the effects of a specific Bifidobacterium strain on emotional behavior and BDNF pathways in mice under chronic stress.
• Used chronic stress-induced depressive mice as a model.
• Administered Bifidobacterium longum subspecies infantis strain CCFM687.
• Evaluated emotional behavior and related physiological markers.
• Analyzed changes in the gut microbiota composition.
• Ingestion of Bifidobacterium longum improved emotional behavior in stressed mice.
• The BDNF pathway showed significant regulation after treatment.
• The gut microbiota composition was notably reshaped.