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February 19, 2026Muscle & Nerve

The Duke MG Patient Registry III . Comparative Effectiveness of Azathioprine and Mycophenolate Mofetil in Generalized Myasthenia Gravis, a Retrospective Single Center Review

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Authors

DSDon B. SandersMLMichael W. LutzAGArindom Goswami

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Overview

Retrospective review compares azathioprine and mycophenolate mofetil effectiveness in generalized myasthenia gravis, indicating treatment implications.

Key Points

  • This study aims to compare the effectiveness of azathioprine and mycophenolate mofetil in treating generalized myasthenia gravis.
  • Retrospective comparative effectiveness analysis using data from the Duke MG Clinic Registry.
  • Inclusion of patients with acetylcholine receptor positive generalized myasthenia gravis receiving treatment for at least 90 days.
  • Time-to-event analysis and Cox proportional hazards modeling were employed.
  • 66.1% of azathioprine patients achieved treatment goals after a median of 17.5 months.
  • 68.5% of mycophenolate mofetil patients reached treatment goals after a median of 10.5 months.
  • Concomitant prednisone use significantly increased treatment goal achievement, p < 0.0001.
  • A positive correlation was found between disease duration at drug initiation and time to treatment goal achievement.

Cite This Study

Sanders et al. (2026) studied this question.

synapsesocial.com/papers/6996a8e3ecb39a600b3f00fdhttps://doi.org/10.1002/mus.70177
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