Abstract Introduction: By using current evidence-based practice mechanisms of pain or pain phenotypes, we can better select candidates for appropriate interventions within oncology rehabilitation. Using subjective and objective assessment criteria for identifying candidates for nocioplastic treatment can result in better treatment outcomes for persistent pain in this traditionally recalcitrant patient population. This has been explored in the context of populations with amputation and CRPS and has yet to be approached within physical therapy in oncology. Purpose: To demonstrate application of nocioplastic assessment and treatment within the realm of physical therapy, oncology specialized practice. Methodology: Case Study of patient with breast cancer and subsequent upper quarter impairments including pain, limitations in shoulder AROM, and trunk lymphedema after mastectomy, axillary radiation, and chemotherapeutic interventions. Results: Noted improved laterality, and shoulder AROM and functional subjective outcomes noted as measured by the Quick-DASH after nocioplastic specific interventions. Conclusions: By treating the central component of pain regarding mastectomy and subsequent current standard of practice for breast cancer, we mitigate impairments more effectively. The prospective surveillance model to impact known impairments, functional activity limitations, and participation limitations could adopt this assessment in at risk populations within the oncology sector. Citation Format: B. Nguyen, S. Anholt, J. Birch. Phantom limb pain patients with Breast cancer: Updates in rehabilitation paradigms abstract. In: Proceedings of the San Antonio Breast Cancer Symposium 2025; 2025 Dec 9-12; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2026;32(4 Suppl):Abstract nr PS5-06-29.
Nguyen et al. (2026) studied this question.