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February 20, 2026Journal of Shoulder and Elbow Surgery0 citations

Isotretinoin Enhances Rotator Cuff Repair by Targeting GATA6 and Reducing Fatty Infiltration

Isotretinoin improves tendon-bone interface healing and inhibits muscle-fatty infiltration through GATA6 activation in a rat model of rotator cuff repair

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Authors

JYJong Pil YoonSPSung-Jin ParkDKDong-Hyun Kim

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Overview

Controlled laboratory study shows isotretinoin improves healing and muscle infiltration in rotator cuff repair, indicating GATA6 may be a key target.

Key Points

  • This research aims to evaluate the therapeutic potential of isotretinoin in improving tendon-bone interface healing and reducing fatty infiltration post-rotator cuff repair in a rat model.
  • Established rotator cuff repair model using 12-week-old male Sprague-Dawley rats.
  • Isotretinoin group received 7 mg/kg daily for six weeks, while the control group received saline.
  • Evaluated fatty infiltration qualitatively and quantitatively in the supraspinatus tendon.
  • Assessed tendon-bone interface healing histologically using the Bonar score and biomechanically with a universal testing machine.
  • Isotretinoin significantly upregulated Gata6 expression and downregulated Caveolin-1 and PPAR-γ.
  • Histological analysis showed improved collagen organization and cellularity at the tendon-bone interface.
  • Biomechanical assessment revealed greater tensile strength and stiffness in the isotretinoin group compared to controls.
  • Fatty infiltration in the supraspinatus muscle was markedly reduced.
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Cite This Study

Yoon et al. (2026) studied this question.

synapsesocial.com/papers/6997b911baf9c852d8c25fbbhttps://doi.org/10.1016/j.jse.2026.02.010
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1High-Dose Statins Preserve Tendon-Bone Interface Healing Without Adversely Affecting Fatty Infiltration in a Rotator Cuff Repair Rat Model2025
  2. 2Leptin receptor signaling mediates the distinct tendon–bone interface reconstruction in rotator cuff tears and osteoporosis-comorbid rotator cuff tears2025
  3. 3GLP-1RA Reduces Supraspinatus Fatty Infiltration and Promotes Functional Recovery in a Rat Model of Rotator Cuff Repair.2025
  4. 4Antiosteoporotic treatment promotes tendon-to-bone healing after rotator cuff repair2026 · 3 citations
  5. 5Effect of alpha-tocopherol and OTR-4131 on muscle degeneration after rotator cuff tear in rats: An experimental protocol2025