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May 16, 2016BMJ953 citationsOpen Access

Prediction models for cardiovascular disease risk in the general population: systematic review

JDJohanna AAG DamenLHLotty HooftESEwoud Schuit

Structured PICO

P
Population
General population
I
Intervention
Cardiovascular disease (CVD) risk prediction models
O
Outcome
Incident cardiovascular disease (CVD)

Due to an excess of poorly validated CVD risk models, future research should prioritize external validation and head-to-head comparison of existing models over developing new ones.

Limitations

  • methodological shortcomings
  • incomplete presentation
  • lack of external validation
  • lack of model impact studies

Abstract

There is an excess of models predicting incident CVD in the general population. The usefulness of most of the models remains unclear owing to methodological shortcomings, incomplete presentation, and lack of external validation and model impact studies. Rather than developing yet another similar CVD risk prediction model, in this era of large datasets, future research should focus on externally validating and comparing head-to-head promising CVD risk models that already exist, on tailoring or even combining these models to local settings, and investigating whether these models can be extended by addition of new predictors.

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Cite This Study

Damen et al. (2016) studied this question.

synapsesocial.com/papers/69990ae5d6891b760e7aa319https://doi.org/10.1136/bmj.i2416
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