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February 21, 2026Biophysical Journal

BPS2026 – L5 determines sensitivity of C. elegans kinesin BMK-1 to the kinesin Eg5-specific inhibitor

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Authors

FTFofou Yonta TostaniTKToru KurosakaNNNobuyuki Nishibe

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Overview

Investigation shows how L5 length alters inhibition in kinesins, suggesting new angles for cancer therapies.

Key Points

  • This research aims to explore how the L5 loop length influences kinesin inhibition sensitivity.
  • Focused on the kinesin BMK-1 in C. elegans
  • Expressed and characterized BMK-1's biochemical properties
  • Assessed the response of BMK-1 to STLC
  • Compared sensitivity with KLP-18 using a mutant model
  • STLC inhibited BMK-1's ATPase and motile activities, but less effectively than Eg5
  • A shortened L5 in BMK-1 lost sensitivity to STLC, retaining ATPase function
  • Study provides insights into a shared inhibition mechanism among kinesins

Cite This Study

Tostani et al. (2026) studied this question.

synapsesocial.com/papers/69990de85b97ab4c14ac2883https://doi.org/10.1016/j.bpj.2025.11.751
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