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February 21, 2026Biophysical Journal0 citations

Insights into the Legionella Dot/Icm secretion system and effector engagement via cryogenic electron

BPS2026 – Structural and mechanistic insights into effector engagement and translocation by the Legionella Dot/Icm secretion system

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Authors

RSRadha P SomarathneRSR ShresthaMZMishghan Zehra

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Overview

Structural characterization reveals crucial role of effector proteins in Legionella pneumophila translocation, suggesting new mechanisms of infection.

Key Points

  • This research explores the structural and mechanistic details of effector engagement via the Legionella secretion system.
  • Purification and biophysical characterization of effector-IcmSW complexes
  • Structural analysis using single particle cryo-electron microscopy
  • Investigation of ATPases role in effector translocation
  • Defined molecular details of substrate engagement
  • Identified structural features promoting effector transport
  • Enhanced understanding of the Dot/Icm system's selection and delivery mechanism

Cite This Study

Somarathne et al. (2026) studied this question.

synapsesocial.com/papers/69990de85b97ab4c14ac28d0https://doi.org/10.1016/j.bpj.2025.11.1060
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