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February 21, 2026Biophysical Journal

BPS2026 – Lipids play a functional role in the potassium transport by KdpFABC

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Authors

AHAdel HusseinXZXihui ZhangDSDavid L. Stokes

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Overview

Cryo-EM reveals lipids' key impact on ATPase function and stability in KdpFABC, indicating their integral role.

Key Points

  • This research investigates the role of lipids in the potassium transport mechanism of KdpFABC.
  • Cryo-EM analysis of KdpFABC in lipid nanodiscs
  • Imaging under active turnover conditions
  • Structural comparison of reaction intermediates
  • Functional testing of mutations in subunit interfaces
  • Lipids are crucial for structure and function of the KdpFABC complex
  • Movement of lipids associates with transition states from E1∼P to E2-P
  • Bulky substitutions in residue mutations disrupt complex function and stability

Cite This Study

Hussein et al. (2026) studied this question.

synapsesocial.com/papers/69990de85b97ab4c14ac295chttps://doi.org/10.1016/j.bpj.2025.11.2005
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