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February 21, 2026Biophysical Journal

BPS2026 – Ruthenium red alters huntingtin aggregation and blocks its ability to associate with and damage lipid membranes

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Authors

PBPinaki BiswasCSChathuranga SiriwardhanaJLJustin Legleiter

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Overview

Screening reveals ruthenium red inhibits huntingtin interaction with lipid membranes, suggesting a therapeutic strategy against HD.

Key Points

  • To explore the effect of ruthenium red on huntingtin aggregation and its interaction with lipid membranes in the context of Huntington's disease.
  • Used a polydiacetylene assay for screening compounds.
  • Investigated the impact of ruthenium red on huntingtin aggregation and membrane binding using various techniques.
  • Assessed the motility phenotype in a C. elegans model of Huntington’s disease.
  • Ruthenium red reduced fibril formation of huntingtin.
  • Altered oligomer structure of huntingtin was observed.
  • Prevented interaction of huntingtin with lipid membranes and improved motility in C. elegans.

Cite This Study

Biswas et al. (2026) studied this question.

synapsesocial.com/papers/69990e015b97ab4c14ac2f24https://doi.org/10.1016/j.bpj.2025.11.2325
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