Plummer-Vinson syndrome (PVS), also known as Paterson-Brown-Kelly syndrome, is a rare disorder marked by iron deficiency anemia, difficulty swallowing, and upper esophageal webs. It predominantly affects middle-aged women and is rarely observed in children. Although the precise mechanisms remain unclear, iron deficiency is frequently implicated as the underlying cause. This report details an unusual pediatric case of PVS in an eight year-old girl with longstanding anemia and progressive dysphagia. Laboratory studies confirmed microcytic hypochromic anemia, and an upper GI Series suggested a proximal esophageal web. Initial treatment with oral iron showed no improvement. Eventually, an esophagogastroduodenoscopy confirmed the presence of a web near the upper esophageal sphincter. Endoscopic dilation was performed successfully, allowing for resolution of symptoms.
Adan et al. (2026) studied this question.
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