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February 21, 2026ACS Applied Materials & Interfaces

Reprogramming the In Vivo Fate of Nanoassemblies: Morphology Regulation to Rod-Like Nanostructures to Enhance Antitumor Efficacy

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Authors

JZJing ZhangSouth China Agricultural UniversityTLTian LiuShenyang Pharmaceutical UniversityYLYaqiao LiShenyang Pharmaceutical University

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Overview

Novel strategies improve tumor targeting and circulation of drug delivery systems, suggesting new avenues for cancer therapy.

Key Points

  • This study aims to develop a method for controlling the morphology of nanoparticles to enhance their effectiveness in cancer treatment.
  • Utilized prodrug nanoassemblies as a model for morphology regulation.
  • Employed an ultrasound-assisted one-step nanoprecipitation method.
  • Transformed spherical nanostructures into uniform rod-like nanostructures.
  • Evaluated the biological impact of these transformations on drug efficacy.
  • Rod-like nanostructures (AR5) showed reduced macrophage uptake and prolonged blood circulation.
  • Enhanced tumor accumulation compared to spherical nanoparticles.
  • Rod-like nanostructures exhibited superior antitumor efficacy.
  • Optimal aspect ratio was identified for effective tumor cell uptake.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69994ba9873532290d01fc00https://doi.org/10.1021/acsami.5c25772
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