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February 21, 2026Neonatology

Clinically Silent Seizures in Neonates with Tuberous Sclerosis: An International Case Series

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Authors

ACAngela M. CurcioRMRomina MoaveroJCJose Luis Boada Cuellar

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Overview

International retrospective study reveals silent seizures in neonates with tuberous sclerosis, suggesting early monitoring is crucial.

Key Points

  • Investigate the prevalence of silent seizures in neonates with Tuberous sclerosis complex using video-EEG monitoring.
  • Conducted an international retrospective study.
  • Monitored neonates with Tuberous sclerosis using long-term video-EEG.
  • Analyzed seizure patterns and genetic variants in patients.
  • Six out of ten neonates exhibited electrographic-only seizures in the first 10 days of life.
  • All patients had TSC2 variants.
  • Many neonates required multiple anti-seizure medications due to difficult-to-treat seizures.

Cite This Study

Curcio et al. (2026) studied this question.

synapsesocial.com/papers/69994d42873532290d021cf6https://doi.org/10.1159/000551140
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