What question did this study set out to answer?

The aim is to identify how different factors affect the benefits of early antibiotic therapy in ICU patients with sepsis without shock.

February 22, 2026Open Access

Early Antibiotic Therapy in Sepsis Without Shock: A Multimethod Study of Heterogeneous Treatment Effects in ICU Patients

PZPeng ZhangXuzhou Medical College TZTongkun ZuoXuzhou Medical College XZXingxing ZhuXuzhou Medical College

Puntos clave

The aim is to identify how different factors affect the benefits of early antibiotic therapy in ICU patients with sepsis without shock.
Analyzed data from ICU patients with sepsis without shock.
Examined treatment effects based on age, comorbidities (CCI, APS III), and liver dysfunction.
Utilized multiple methods to assess the impact of time-to-antibiotics.
Older patients and those with higher CCI and APS III scores benefit more from faster antibiotic treatment.
Patients with acute liver dysfunction showed increased positive outcomes with shorter time-to-antibiotics.

Resumen

Among ICU patients with sepsis without shock, those who are older, have higher CCI or APS III, or acute liver dysfunction are more likely to benefit from shorter time-to-antibiotics.

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Cite This Study

Zhang et al. (Thu,) studied this question.

synapsesocial.com/papers/699a9cc6482488d673cd27ba https://doi.org/https://doi.org/10.1007/s40121-026-01316-5

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