The role of short-chain fatty acids in spinal cord injury: A systematic review of human and animal evidence

Key Points

• Examine the therapeutic potential of short-chain fatty acids and gut microbiota in spinal cord injury recovery.
• Systematic review of existing human and animal studies
• Analysis of the role of short-chain fatty acids in recovery mechanisms
• Evaluation of gut microbiota's impact on spinal cord injury outcomes
• Promising results noted in animal models regarding SCFAs
• Limited evidence found from human studies on SCFA effectiveness
• Highlights a need for further human-based research on gut microbiota and SCFAs