What question did this study set out to answer?

To highlight how pretibial myxedema can lead to the diagnosis of Graves' disease and papillary thyroid carcinoma.

February 22, 2026Open Access

A Case of Pretibial Myxedema Leading to the Diagnosis of Graves' Disease and Papillary Thyroid Carcinoma

Key Points

To highlight how pretibial myxedema can lead to the diagnosis of Graves' disease and papillary thyroid carcinoma.
Conducted histopathological examination for diagnosis of pretibial myxedema
Performed blood tests to assess thyroid function including TSH, free T3, free T4 and antibodies
Utilized ultrasound for thyroid examination
Conducted fine-needle aspiration cytology for nodular lesions
Diagnosed pretibial myxedema through histological findings
Confirmed Graves' disease based on low TSH and elevated thyroid hormones
Identified papillary thyroid carcinoma via fine-needle aspiration results
Emphasized the rarity of pretibial myxedema but its clinical significance in thyroid diseases

Abstract

76 歳，女性。約 8 カ月前に両側下腿伸側に自覚症状を伴わない紅褐色局面が出現した。病理組織学的に膠原線維束間の開大とムチンの沈着があり，脛骨前粘液水腫と診断した。血液検査では TSH の低下，遊離 T3，遊離 T4，甲状腺刺激抗体，TSH レセプター抗体の上昇がみられ，Basedow 病と診断した。また甲状腺エコー検査では右葉に結節性病変を認め，甲状腺穿刺吸引細胞診の結果，甲状腺乳頭癌と診断した。脛骨前粘液水腫は稀ではあるが Basedow 病や甲状腺癌発見の契機となることがある。下腿伸側に局面，結節，圧痕を残さない浮腫を認めた際は本症を念頭に置いて皮膚生検を施行し，本症診断後は既往の有無にかかわらず甲状腺の精査を行うことが勧められる。

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Discussion

Authors

Takafumi HISAMOTO

Hiroshi Uchida

Journals

The Nishinihon Journal of Dermatology

Actions

Institutions

Shimonoseki City Hospital

References and Citations

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Building similarity graph...

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A Case of Pretibial Myxedema Leading to the Diagnosis of Graves' Disease and Papillary Thyroid Carcinoma

Key Points

Abstract

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Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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