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February 22, 2026Journal of Clinical ImmunologyOpen Access

A Cohort Study of 38 Classic Wiskott-Aldrich Syndrome Cases with Six Novel Mutations

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Authors

ARAnahita RazaghianMBMohsen BadalzadehAHAmir Ali Hamidieh

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Overview

Cohort study evaluates clinical outcomes in Wiskott-Aldrich syndrome patients, highlighting crucial implications for treatment.

Key Points

  • This study aims to examine the frequency of clinical manifestations and outcomes in Wiskott-Aldrich syndrome patients.
  • Retrospective evaluation of 38 boys with Wiskott-Aldrich syndrome
  • Comparison of clinical outcomes between patients with and without hematopoietic stem cell transplantation (HSCT)
  • Data collection from the Immunology, Asthma, and Allergy Research Institute registry from 2006 to 2023
  • All patients presented with allergies (100%); infections were observed in 97.4% of cases
  • Disease-free survival in transplant patients was 62.5%, with a mortality rate of 68.2% in non-transplant patients
  • Identified six novel mutations in the WAS gene among 36 analyzed patients

Cite This Study

Razaghian et al. (2026) studied this question.

synapsesocial.com/papers/699a9d50482488d673cd31a7https://doi.org/10.1007/s10875-026-01986-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1New insights into Wiskott-Aldrich syndrome: ten novel WAS mutations and their clinical impact in a Brazilian cohort2025
  2. 2Wiskott-Aldrich Syndrome: A Report of a Rare X-Linked Disorder2024 · 1 citations
  3. 3Clinical Manifestations of Wiskott-Aldrich Syndrome in an Iranian Patient2024
  4. 4Wiskott-Aldrich Syndrome With Severe Thrombocytopenia and Hemorrhagic Manifestations: A Case Report2026
  5. 5Wiskott–Aldrich Syndrome: A Rare X-Linked Immunodeficiency Disorder and Its Clinical Implications2026