Pharmacist-led mHealth intervention reduced 6-month systolic BP by 5.8 mmHg and sustained reduction at 12 months in high-risk hypertensive patients.
Does a pharmacist-led mobile health intervention (mGlide) reduce systolic blood pressure in adult patients with uncontrolled hypertension?
A pharmacist-led mobile health intervention significantly reduced 6-month systolic blood pressure compared to usual care in diverse patients with uncontrolled hypertension.
BACKGROUND: The mGlide RCT (randomized controlled trial) evaluated whether a pharmacist-led, mobile health technology facilitated care model improves hypertension control in diverse populations. METHODS: We recruited adult English, Spanish, or Hmong-speaking patients with uncontrolled hypertension from a large health care system and smaller community clinics serving low-income patients. Participants were randomized 1:1 to mGlide or usual care. The 6-month intervention included daily blood pressure (BP) self-monitoring using a smartphone and wireless monitor, automated app-based data sharing, and responsive medication adjustment by a pharmacist-led provider-team. Comparison participants received a digital monitor. Outcomes included mean 6-month systolic BP (SBP), 12-month sustained BP control, 24-hour ambulatory BP and patient activation. RESULTS: A total of 395 participants (mean age, 66.9 years; 46.6% women; mean SD SBP, 143.4 16.5 mm Hg) were randomized to mGlide (n=198) or usual care (n=197). Mean (SD) 6-month SBP (mm Hg) was lower in the mGlide arm (128.1 13.9 versus 134.0 16.0). The adjusted mean difference between groups for the primary outcome of 6-month SBP favored mGlide: −5.8 mm Hg (95% CI, −8.6 to −3.0), sustained at 12 months (−5.7 mm Hg −8.7 to −2.6). The mGlide arm also had a 4.8 mm Hg ( P =0.014) lower 24-hour average ambulatory SBP. The 6-month intervention effect varied significantly by activation level, with a difference of −12.6 mm Hg (−20.5 to −4.8) SBP among the lowest versus −2.5 mm Hg (−6.5 to 1.6) among the highest activation level participants. CONCLUSIONS: A mobile health-facilitated care model with pharmacist-led medication adjustment was effective in lowering BP in diverse populations. Patients with low activation benefited more from the intervention; activation levels may inform efficient intervention selection. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03612271.
Lakshminarayan et al. (2026) studied this question. Pharmacist-led mHealth intervention reduced 6-month systolic BP by 5.8 mmHg and sustained reduction at 12 months in high-risk hypertensive patients.