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February 22, 2026AntibioticsOpen Access

Biofilm Formation in Chicken-Derived Extraintestinal Pathogenic Escherichia coli Alters the Expression of Biofilm- and Virulence-Associated Genes

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Authors

YHYanze HeNKNianling KuangZCZhihui Chang

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Overview

Demonstrates that biofilm formation alters the expression of specific genes in ExPEC, suggesting new infection control strategies.

Key Points

  • This research investigates how biofilm formation affects the expression of biofilm- and virulence-associated genes in chicken-derived ExPEC strains.
  • Optimized biofilm formation conditions for three ExPEC strains using an orthogonal experimental design.
  • Quantified biofilm biomass with crystal violet staining.
  • Compared transcription levels of specific biofilm and virulence genes using Reverse Transcription-quantitative PCR.
  • Nutrient-rich media consistently promoted rapid biofilm formation across strains.
  • Significant upregulation of biofilm-associated genes such as flhC, tolA, qseC, mhpB, and bdcR (p < 0.05).
  • Virulence genes eaeA, LT, fimH, ompF, and iss were significantly upregulated, while Sta levels were reduced (p < 0.05).

Cite This Study

He et al. (2026) studied this question.

synapsesocial.com/papers/699a9d50482488d673cd325chttps://doi.org/10.3390/antibiotics15020227
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