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February 22, 2026Inorganic Chemistry Frontiers1 citationsOpen Access

Flavoplatins: Photoactivated platinum(IV) prodrugs bearing axial N-donors that trigger pyroptosis and reduce drug resistance

QZQiyuan ZhouNCNang-Hei ChuJXJiaqian Xu

Key Points

  • This research aims to explore the effectiveness of N-donor ligands in photoactivated platinum(IV) prodrugs for triggering cell death.
  • Synthesize platinum(IV) prodrugs with axial N-donors.
  • Evaluate the photoactivation process and its impact on cancer cells.
  • Assess the induction of pyroptosis and resistance mechanisms.
  • N-donor platinum(IV) prodrugs successfully induce pyroptosis in targeted cells.
  • The photoactivation enhances anticancer activity compared to traditional Pt(II) drugs.
  • Reduced drug resistance observed in treated cancer cells.

Abstract

Photoactivated Pt(IV) anticancer prodrugs derived from clinical Pt(II) drugs have garnered significant attention in recent years, with O-donor ligands being the most commonly used photosensitive axial ligands. N-donor ligands, however,...

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Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/699a9d8e482488d673cd3741https://doi.org/10.1039/d6qi00078a
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