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February 22, 2026Chemical Communications0 citations

Enhancing photodynamic therapy effects by a glutathione-responsive SO2 donor as nanocarriers for cancer therapy

SXShaoqi XieMLMengqi LiuYWYihan Wang

Key Points

  • The research aims to improve photodynamic therapy effects for cancer using sulfur dioxide (SO2) donors as nanocarriers.
  • Constructed nanodrugs DNS/Y6-DIN using modified amphiphilic pillararene and a photosensitizer.
  • Evaluated SO2 and reactive oxygen species (ROS) generation capabilities of the nanodrugs.
  • Assessed therapeutic effects in cancer models.
  • The nanodrugs demonstrated excellent SO2 generation ability.
  • Significant increase in ROS levels was observed, enhancing photodynamic therapy efficacy.
  • The approach suggests a promising method for improved cancer treatment outcomes.

Abstract

Herein, the nanodrugs DNS/Y6-DIN with excellent SO2 and ROS (reactive oxygen species) generation ability were constructed by a 2,4-dinitrobenzenesulfonamide group modified amphiphilic pillararene (WP5-PEG-DNS) and an A−D−A photosensitizer Y6-DIN. The...

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Cite This Study

Xie et al. (2026) studied this question.

synapsesocial.com/papers/699a9e00482488d673cd4601https://doi.org/10.1039/d6cc00058d
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