PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
February 22, 2026Clinical Cancer Research2 citations

Impact of GLP-1 Receptor Agonist Use on Pathologic Complete Response in HER2-Positive Breast Cancer

Abstract PS3-11-29: Impact of GLP-1 Receptor Agonist Use on Pathologic Complete Response in HER2-Positive Breast Cancer Treated with Neoadjuvant TCHP

View Full Paper

Authors

DPD. Urueta PortilloMCM. Mazo Canola

Discussion

Loading...

Member takes

Overview

Retrospective analysis reveals a trend of lower pCR rates in HER2-positive breast cancer with GLP-1RA use, suggesting a need for further research.

Key Points

  • This study aims to evaluate the impact of GLP-1 receptor agonist exposure on pathologic complete response rates in HER2-positive breast cancer patients undergoing neoadjuvant TCHP chemotherapy.
  • Retrospective analysis of HER2-positive breast cancer patients treated at UT Health Mays Cancer Center.
  • Patients were categorized based on GLP-1RA exposure during neoadjuvant therapy.
  • Primary endpoint assessed was pathologic complete response (ypT0/is, ypN0).
  • Collected covariates included age, body mass index (BMI), diabetes status, hormone receptor status, race, and clinical stage.
  • Statistical methods included Fisher’s exact and chi-square tests for group differences.
  • Among 42 patients, 6 (14%) used GLP-1 receptor agonists.
  • The pCR rate was 33% (2/6) in GLP-1RA users compared to 58% (21/36) in non-users (p=0.21).
  • The pCR rate was 56% among patients on other diabetes medications (n=9) and 55% among those on no diabetes medications (n=33).
  • Healthy response rates were similar between GLP-1RA users and non-users in terms of age and hormone receptor positivity, with no significant racial association (p=0.44).
  • Findings indicate a trend towards lower pCR rates with GLP-1RA use, highlighting the need for further investigation.
Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Portillo et al. (2026) studied this question.

synapsesocial.com/papers/699a9e20482488d673cd4882https://doi.org/10.1158/1557-3265.sabcs25-ps3-11-29
Ask AI
Helpful
Bookmark
Share
View Full Paper