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February 23, 2026International Journal of Clinical OncologyOpen Access

Turning pancreatic cancer from cold to hot: the promise of a p53-expressing oncolytic adenovirus (OBP-702)

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Authors

SKShinji KurodaHTH. TazawaMHMasashi Hashimoto

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Overview

Oncolytic adenovirus OBP-702 enhances immune checkpoint inhibitor responses in pancreatic cancer, suggesting improved treatment outcomes.

Key Points

  • The research aims to develop and evaluate OBP-702, an oncolytic adenovirus, for enhancing immune responses in pancreatic cancer.
  • Developed OBP-702, a p53-armed oncolytic adenovirus.
  • Conducted preclinical studies to assess cytotoxicity and immunogenicity.
  • Evaluated the effects of OBP-702 on the tumor microenvironment and immune cell activity.
  • OBP-702 demonstrated robust cytotoxicity through p53-mediated apoptosis and autophagy.
  • Induced immunogenic cell death and activated dendritic cells, promoting T-cell responses.
  • Remodeled the immunosuppressive tumor microenvironment by reducing GM-CSF and targeting CAFs.

Cite This Study

Kuroda et al. (2026) studied this question.

synapsesocial.com/papers/699ba05e72792ae9fd86fc1fhttps://doi.org/10.1007/s10147-026-02991-7
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