Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 23, 2026Advanced Functional Materials

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain (Adv. Funct. Mater. 15/2026)

View Full Paper
Ask AI
Bookmark
Share

Authors

ETEsra TürkerMMMateo S. Andrade MierJFJessica Faber

Discussion

Loading...

Member takes

Overview

3D biofabricated model reveals breast tumor increases neuronal firing through gap junctions in brain tissue.

Key Points

  • Investigate how breast tumors influence neuronal activity using a 3D biofabricated brain model.
  • Developed a 3D biofabricated model mimicking the brain extracellular matrix.
  • Evaluated interactions between metastatic breast tumor cells, neurons, and astrocytes.
  • Measured neuronal firing capacity in the presence of tumor cells.
  • Breast tumor cells increased the firing capacity of neurons.
  • Tumor cells created pseudosynaptic contacts with neurons.
  • Gap junctions formed between tumor cells and astrocytes.

Cite This Study

Türker et al. (2026) studied this question.

synapsesocial.com/papers/699ba07072792ae9fd87010ahttps://doi.org/10.1002/adfm.74287
View Full Paper
Ask AI
Bookmark
Share