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February 23, 2026JACC Case Reports0 citationsOpen Access

Dilated Cardiomyopathy and Later Onset Limb-Girdle Muscular Dystrophy Associated With Fukutin and Lamin A/C Mutations

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APAlejandra Cardona PerezRMRenee MoenningCBCynthia Bodkin

Key Points

  • This research explores the link between dilated cardiomyopathy and limb-girdle muscular dystrophy caused by specific genetic mutations.
  • Analyzed clinical cases of dilated cardiomyopathy and limb-girdle muscular dystrophy.
  • Performed genetic testing to identify fukutin and lamin A/C mutations.
  • Evaluated the implications of findings for cardiac transplant planning.
  • Identified genetic mutations in patients with isolated cardiac symptoms.
  • Demonstrated that early genetic testing aids in long-term care and counseling.
  • Highlighted the potential for significant cardiac issues arising from these mutations.

Abstract

These cases demonstrate that genetically mediated DCM may initially present as isolated cardiac disease. Early genetic testing can guide transplant planning, long-term care, and family counseling.

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Cite This Study

Perez et al. (2026) studied this question.

synapsesocial.com/papers/699bee1c1c6c6bad5397fd15https://doi.org/10.1016/j.jaccas.2026.107038
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