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February 24, 2026Targeted Oncology0 citationsOpen Access

Age-Related Differences in Severe Adverse Events During Maintenance Therapy with PARP Inhibitors: A Retrospective Cohort Study in Japanese Patients with Ovarian Cancer

KNKeiko NishimyoKIKoichi IshikawaDADaisuke Aoki

Key Points

  • To investigate age-related differences in adverse events during PARP inhibitor maintenance therapy in ovarian cancer patients.
  • Conducted a retrospective cohort study in Japanese ovarian cancer patients
  • Analyzed adverse events associated with PARP inhibitor maintenance therapy
  • Compared outcomes between older and younger patient groups
  • Older patients on olaparib monotherapy had a higher incidence of clinically significant neutropenia
  • Overall tolerability of PARP inhibitor therapy was reasonable in the older cohort

Abstract

Overall, PARP inhibitor maintenance therapy appeared to be generally tolerated in older patients in this real-world cohort. However, older individuals who received olaparib monotherapy experienced a significantly higher incidence of clinically significant neutropenia, indicating the need for careful monitoring and individualized dose management in this subgroup.

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Cite This Study

Nishimyo et al. (2026) studied this question.

synapsesocial.com/papers/699d3f9ede8e28729cf6445ehttps://doi.org/10.1007/s11523-026-01202-7
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