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February 24, 2026Journal of Perioperative Practice0 citations

Efficacy of intranasal insulin in reducing the incidence of postoperative delirium: A systematic review and meta-analysis of randomised controlled trials

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ADArusha DesaiRBRahul BishtECEsteban Marcelo Mogrovejo Carrión

Key Points

  • The research aims to evaluate the effectiveness of intranasal insulin in lowering postoperative delirium rates following surgery.
  • Conducted a systematic review of randomized controlled trials.
  • Analyzed data on the incidence of postoperative delirium.
  • Compared outcomes in patients receiving intranasal insulin versus control.
  • Found a significant reduction in postoperative delirium incidence with intranasal insulin administration.
  • Highlighted consistent results across multiple trials.

Abstract

Perioperative intranasal insulin significantly reduced the incidence of postoperative delirium in patients undergoing surgery.

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Cite This Study

Desai et al. (2026) studied this question.

synapsesocial.com/papers/699d3fb3de8e28729cf645c4https://doi.org/10.1177/17504589261421004
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Delirium is associated with early postoperative cognitive dysfunction2008 · 184 citations
  2. 2Motor Subtypes of Postoperative Delirium in Older Adults2011 · 264 citations
  3. 3Effects of Intranasal Insulin Pretreatment on Preoperative Sleep Quality and Postoperative Delirium in Patients Undergoing Valve Replacement for Rheumatic Heart Disease2024 · 20 citations
  4. 4Antipsychotic Medication for Prevention and Treatment of Delirium in Hospitalized Adults: A Systematic Review and Meta‐Analysis2016 · 507 citations
  5. 5Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans2016 · 633 citations