Associations of Myocardial Stress Markers With Kidney Function and Chronic Kidney Disease

Lin et al. (2026) conducted an observational in General adult population from Europe with variable cardiovascular disease and diabetes status, assessed for kidney function and chronic kidney disease (n=61,830). Higher levels of myocardial stress markers (NT-proBNP, MR-proANP, MR-proADM) vs. Lower levels of these markers (group 1) was evaluated on Kidney function measured by estimated glomerular filtration rate (eGFRcr-cys) and prevalence/incidence of chronic kidney disease (CKDcr-cys defined as eGFR < 60 ml/min/1.73m2) (Cross-sectional: For each 1 SD increase in log-transformed NT-proBNP, eGFRcr-cys decreased by 2.35 ml/min/1.73m2; Odds ratio (OR) for prevalent CKDcr-cys was 1.81 (95% CI 1.72–1.90); Highest NT-proBNP group (≥300 pg/ml) had OR 5.72 (95% CI 4.82–6.78) vs lowest group (<48 pg/ml). Longitudinal: For each 1 SD increase in log-transformed NT-proBNP, 10-year decline in eGFRcr-cys was –1.37 ml/min/1.73m2 (95% CI –1.77 to –0.98); Hazard ratio (HR) for incident CKDcr-cys was 1.39 (95% CI 1.20–1.62); Highest NT-proBNP group had HR 4.40 (95% CI 2.63–7.36) vs lowest group., 95% CI As stated above., p=All associations statistically significant with p<0.05, many p<0.001). Higher levels of NT-proBNP were associated with a 2.35 ml/min/1.73m2 lower eGFR (per 1 SD increase) and a 1.81-fold higher odds of prevalent CKD cross-sectionally, and with a 1.37 ml/min/1.73m2 faster 10-year eGFR decline and 1.39-fold higher risk of incident CKD longitudinally in a European general adult population.