Metagenomic analysis of the human gut virome reveals functional signatures and viral stability across hospitalized and non-hospitalized diarrheal and non-diarrheal individuals
Metagenomic analysis reveals functional shifts in the gut virome of hospitalized and non-hospitalized individuals, highlighting viral resilience.
Key Points
This research aims to explore the taxonomic composition and functional potential of the gut virome in various clinical conditions, specifically in Latin American populations.
Hybrid metagenomic analysis of 37 fecal samples from different groups
Taxonomic and functional profiling of viruses
Detection of viral auxiliary metabolic genes (vAMGs)
Identified 494 high-quality viral operational taxonomic units (vOTUs)
Non-diarrheic individuals had a higher diversity of vAMGs compared to hospitalized groups
Modest shifts in functional composition linked to diarrhea status rather than hospitalization