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February 24, 2026Expert Opinion on Biological Therapy0 citations

Biologic treatment patterns and challenges in defining difficult-to-treat disease in children with polyarticular juvenile idiopathic arthritis: a real-world study

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SUSıla Atamyıldız UçarETEray TunceNÇNeslihan Kara Çanlıoğlu

Key Points

  • The research aims to explore treatment patterns and the challenges in identifying difficult-to-treat disease in children with polyarticular juvenile idiopathic arthritis.
  • Analyzed real-world data from children suffering from polyarticular juvenile idiopathic arthritis.
  • Evaluated treatment patterns regarding biologic therapies.
  • Assessed associated markers like temporomandibular joint involvement and inflammatory markers.
  • Difficult-to-treat courses correlated with higher disease activity at the start of biologic treatment.
  • Elevated inflammatory markers were noted in patients classified as difficult-to-treat.
  • Temporomandibular joint involvement was linked to the challenges in treatment.

Abstract

D2T course was associated with temporomandibular joint involvement, elevated inflammatory markers, and higher disease activity at the initiation of the first biologic therapy.

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Cite This Study

Uçar et al. (2026) studied this question.

synapsesocial.com/papers/699d401ade8e28729cf65283https://doi.org/10.1080/14712598.2026.2635527
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical use of biologics in juvenile idiopathic arthritis: lessons learned from real-world studies2025 · 2 citations
  2. 2Safety and efficacy of tofacitinib for the treatment of patients with juvenile idiopathic arthritis: preliminary results of an open-label, long-term extension study2024 · 24 citations
  3. 3Experience with upadacitinib in refractory polyarticular juvenile idiopathic arthritis2025 · 5 citations
  4. 4Effects of Biologics on Temporomandibular Joint Inflammation in Juvenile Idiopathic Arthritis2024 · 3 citations
  5. 5Development and validation of a composite disease activity score for juvenile idiopathic arthritis2009 · 820 citations