February 25, 2026

Neurocognitive and psychosocial burden in patients with end-stage renal disease: A pilot study

Q: What does this research mean for the field?

Patients with end-stage renal disease (ESRD) undergoing hemodialysis therapy experience significant impairments in cognitive performance, psychological well-being, and quality of life compared to healthy controls. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Puntos clave

Evaluate cognitive function, psychological profile, and quality of life in patients with end-stage renal disease undergoing hemodialysis.
Participants included 26 adults: 13 ESRD patients and 13 healthy controls.
Cognitive performance was assessed using multiple standardized tests.
Psychological status was measured with DASS-21 for depression, anxiety, and stress.
Quality of life was evaluated using the SF-36 questionnaire.
ESRD patients performed significantly worse than controls on vigilance and verbal fluency tests.
High prevalence of severe psychological symptoms: 51.8% severe stress, 56.7% severe depression, and 90.8% severe anxiety.
ESRD group scored significantly lower on multiple quality of life domains.

Resumen

This study aimed to evaluate cognitive function, psychological profile, and quality of life in patients with end-stage renal disease (ESRD) undergoing hemodialysis therapy. Twenty-six participants were enrolled: 13 ESRD patients undergoing hemodialysis therapy and 13 age-matched healthy controls (CTR group) (mean age: 35 ± 4.3 years). Cognitive performance was assessed using the reaction time test, vigilance test, Stroop test, verbal fluency test, and Rey Auditory Verbal Learning Test (RAVLT). Psychological status was measured using the Depression, Anxiety, and Stress Scales (DASS-21), while quality of life was evaluated with the SF-36 questionnaire. ESRD patients showed significantly poorer performance than CTR on the vigilance test (p p p p p p < 0.001). No significant difference was found in emotional well-being between groups.In conclusion, patients with ESRD experience marked impairments in cognitive performance, psychological well-being, and quality of life, highlighting the need for integrated medical and psychological care.

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