Respiratory Oscillometry and Multimodal Lung Function Assessment of Elexacaftor/Tezacaftor/Ivacaftor Response in Children and Young Adults With Cystic Fibrosis

Puntos clave

• To evaluate the effectiveness of Elexacaftor/Tezacaftor/Ivacaftor (ETI) on lung function metrics in cystic fibrosis patients.
• Analyzed oscillometry parameters before and after ETI treatment.
• Included multiple genotype groups for comparison.
• Explored the relationship between FOT parameters and other lung function metrics like LCI and spirometry.
• Significant improvement in oscillometry parameters observed post-ETI treatment.
• Further investigation needed to validate FOT parameters as surrogates for LCI or spirometry.