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Synapse
February 25, 20260 citations

Comparative Evaluation of Topical Stabilized Retinaldehyde 0.1% vs. 0.05% on Skin Biophysical and Biomechanical Parameters.

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ADAnna DedaWOWiktoria OdrzywołekALAgata Lebiedowska

Key Points

  • This research aims to compare the effects of two concentrations of topical stabilized retinaldehyde on skin parameters.
  • Compared 0.1% and 0.05% stabilized retinaldehyde formulations
  • Evaluated skin biophysical and biomechanical parameters
  • Conducted assessments over a 24-week period
  • Significant improvements in skin texture with 0.1% concentration
  • Notable increases in skin firmness observed
  • Higher concentration demonstrated better outcomes for long-term therapy

Abstract

Results indicated significant improvements in skin texture and firmness, particularly with the higher 0.1% concentration of RAL over 24-week period, making it a promising option for long-term skin rejuvenation therapy.

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Cite This Study

Deda et al. (2026) studied this question.

synapsesocial.com/papers/699e9143f5123be5ed04eb71https://doi.org/10.1111/srt.70326
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy and Tolerability of Topical 0.1% Stabilized Bioactive Retinol for Photoaging: A Vehicle-Controlled Integrated Analysis2024 · 5 citations
  2. 2Barrier Function and Biophysical Effects of 0.104% and 0.247% Retinol Creams in Mature Facial Skin: A Prospective Study2026
  3. 3A Double-Blind Randomized Preliminary Study Comparing the Efficacy and Tolerance of a New Retinoid Combination with the Equivalent Retinol Concentration in the Treatment of Skin Aging2026
  4. 4Enhancing Facial Rejuvenation Outcomes With a Novel Retinaldehyde‐Based Cream: A Comparative Randomized Intra‐Individual Study2025 · 2 citations
  5. 5Effectiveness and safety of topical L-ascorbic acid 15% serum compared to retinol 0.1% serum for skin aging: a double-blind randomized controlled trial study2026