What question did this study set out to answer?

This research aims to explore how YBX1 influences corneal neovascularization (CoNV) through m5C modification of specific mRNAs.

February 25, 2026Open Access

YBX1 Modulated Corneal Neovascularization Induced by Alkali Burn via m 5 C-Dependent Regulation of the STAT3/HIF-1α/VEGFA Axis

Puntos clave

This research aims to explore how YBX1 influences corneal neovascularization (CoNV) through m5C modification of specific mRNAs.
Investigated the role of YBX1 in CoNV using an alkali burn model.
Analyzed the stability of m5C-modified mRNAs for STAT3 and VEGFA.
Evaluated the effects of YBX1 inhibition with SII on the JAK1/STAT3/HIF-1α pathway.
Inhibition of YBX1 decreased corneal neovascularization.
Reduced stability of m5C-modified mRNAs for STAT3 and VEGFA was observed.
The JAK1/STAT3/HIF-1α axis was effectively counteracted by the YBX1 inhibitor.

Resumen

Our study unveils a novel epitranscriptomic mechanism in which YBX1 drives CoNV by regulating the stability of m5C-modified STAT3 and VEGFA mRNAs, thereby activating the JAK1/STAT3/HIF-1α axis. Inhibition of YBX1 with SII effectively counteracts this pathway, highlighting YBX1 as an attractive candidate for intervention against sight-threatening CoNV.

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Cite This Study

Wang et al. (Mon,) studied this question.

synapsesocial.com/papers/699e9166f5123be5ed04ee6e https://doi.org/https://doi.org/10.1167/iovs.67.2.42

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