Gray matter asymmetry alterations in perinatally HIV-exposed adolescents: evidence from structural neuroimaging

Key Points

• Examine gray matter asymmetry and structural differences in perinatally HIV-exposed adolescents compared to peers.
• Utilized structural neuroimaging to assess brain structure and asymmetry.
• Compared adolescents living with HIV (ALHIV) and HIV-exposed uninfected (HEU) individuals to typically developing (TD) peers.
• Analyzed localized brain alterations associated with infection status.
• ALHIV and HEU exhibited significant deviations in gray matter asymmetry compared to TD peers.
• Perinatal HIV exposure resulted in additional localized structural changes in the brain.