Restrictive versus standard hyperhydration during high-dose cyclophosphamide for hematopoietic stem cell transplantation: a retrospective cohort study | Synapse
February 25, 2026Open Access
Restrictive versus standard hyperhydration during high-dose cyclophosphamide for hematopoietic stem cell transplantation: a retrospective cohort study
Puntos clave
The study aims to compare the incidence of hydration complications under two different hydration regimens during high-dose cyclophosphamide treatment.
Retrospective review of patients undergoing hematopoietic stem cell transplantation
Comparison of restrictive and standard hyperhydration regimens
Assessment of hydration complications and electrolyte imbalances
No higher incidence of hydration complications observed with restrictive hydration
Electrolyte imbalances were not increased in the restrictive group
Resumen
In this retrospective single-center cohort, we did not observe a higher incidence of HC or electrolyte imbalances with a restrictive hydration regimen compared to the original regimen.