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February 26, 2026SHILAP Revista de lepidopterología0 citationsOpen Access

When Fever Defies Diagnosis: Wissler–Fanconi Syndrome as an Atypical Presentation of Adult‐Onset Still's Disease

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ANAttaina NajeebKTKamran TajAQAqsa Abdul Qader

Key Points

  • To highlight the presentation of Wissler–Fanconi syndrome as a variant of Adult‐Onset Still's Disease with atypical symptoms.
  • Case review of young adults presenting with fever and inflammatory arthritis.
  • Assessment of the role of ferritin testing in diagnosis.
  • Evaluation of treatment options and timing for immunosuppressive therapy.
  • Early recognition of Adult‐Onset Still's Disease can lead to timely intervention.
  • Ferritin testing aids in distinguishing the diagnosis, preventing delays in care.
  • Immunosuppressive therapy improves outcomes for patients with this syndrome.

Abstract

ABSTRACT Adult‐onset Still's disease should be considered in young adults presenting with fever of unknown origin and inflammatory arthritis, even in the absence of rash or sore throat. Recognition of the Wissler–Fanconi variant and early ferritin testing can prevent diagnostic delay and enable prompt, effective immunosuppressive therapy.

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Cite This Study

Najeeb et al. (2026) studied this question.

synapsesocial.com/papers/699f95ba1bc9fecf3dab3d75https://doi.org/10.1002/ccr3.72133
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