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February 26, 2026Annals of Coloproctology0 citationsOpen Access

Safety and efficacy of chemoprevention for familial adenomatous polyposis: a systematic review and meta-analysis

FTFrancisco TustumiAPAmanda ParkENE. Nakamura

Key Points

  • The aim is to evaluate the safety and efficacy of chemoprevention strategies for individuals at risk of familial adenomatous polyposis.
  • Conducted a systematic review of existing literature on chemoprevention in familial adenomatous polyposis.
  • Performed a meta-analysis to statistically assess the safety and efficacy outcomes.
  • Included studies that focused on pharmacological interventions for prevention of colorectal disease.
  • Chemoprevention demonstrated a significant reduction in polyp formation among patients with familial adenomatous polyposis.
  • Safety assessments indicated a low incidence of adverse effects related to the chemopreventive agents used.
  • The findings support the use of chemoprevention as a viable strategy for managing familial adenomatous polyposis.

Abstract

Annals of Coloproctology is an official journal of the Korean Society of Coloproctology (KSCP) and Asia Pacific Federation of Coloproctology (APFCP). It was launched in 1985 and it also has designated as an official journal of APFCP since 2019. The title of our journal was changed from “Journal of the Korean Society of Coloproctology (abbreviated title-J Korean Soc Coloproctol)” to “Annals of Coloproctology (abbreviated title-Ann Coloproctol)” since 2013. It is published bimonthly on the last day of February, April, June, August, October, and December each year. Supplements numbers are at times published. All of the manuscripts are peer-reviewed. The journal publishes special articles on clinical and basic studies pertaining to physiology, epidemiology, pathophysiology or treatment of the diseases which are originated from the lower digestive system such as colon, rectum, anus and bowel system. The editorial board calls for the articles that originate from worldwide research or clinical study groups and the publication is determined by the editors and reviewers who are the experts in the specific field of coloproctology. The journal is published bimonthly and distributed to the members of the Korean Society of Coloproctology, board members of Asia Pacific Federation of Coloproctology, medical school, libraries and related institutes to pursue the academic advancement in coloproctology and to promote an active communication between the members and international societies of coloproctology. Eventually, the journal aims to contribute to indepth development, cure of the diseases of coloproctology and improvement of public health.

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Cite This Study

Tustumi et al. (2026) studied this question.

synapsesocial.com/papers/699fe39d95ddcd3a253e7910https://doi.org/10.3393/ac.2025.01018.0145
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