Enantioselective Bioreduction of Prochiral Aromatic and Heteroaromatic Ketones Catalyzed by and Cells

Key Points

• To develop a method for synthesizing optically pure secondary heteroaromatic alcohols via bioreduction of prochiral ketones.
• Applied asymmetric reduction on prochiral ketones.
• Utilized -bromophenylethanone as a primary example.
• Examined the impact of substituent positions on stereoselectivity.
• Achieved optically pure secondary heteroaromatic alcohols.
• Demonstrated variations in efficiency based on substituent positions.
• Noted significant stereoselectivity in carbonyl group bioreduction.