The aim of this paper is to examine the possibility of using electrospun poly(vinylpyrrolidone) (PVP) fibers as a carrier of the phytoestrogen biochanin A (BCA). PVP fibers were prepared with different BCA content by using electrospinning method at specific process parameters. Produced electrospun PVP-BCA fibers were characterized by chemical, physical-mechanical and biological methods. SEM, DSC and FTIR analyzes showed that there are no strong interactions between PVP and BCA molecules, neither thermal changes in tested temperature range (50 - 250?C) and that equal distribution of BCA in the PVP electrospun fibers was achieved. Physico-mechanical tests showed that the physical properties and wetting angle of PVP change in the presence of BCA. Testing of electrospun PVP fibres with and without BCA on L929 fibroblasts in direct contact assay in vitro revealed a significant effect on proliferation and migration of fibroblasts. Biological tests confirmed that the system of electrospun PVP-BCA fibers can become suitable for the treatment of complicated wounds, where in the first stage of treatment the damaged tissue should be removed by the activity of electrospun PVP-BCA fibers. Another possibility of using electrospun PVP-BCA fibers is for the treatment of facial skin for the exfoliation intent.
Gajić et al. (Thu,) studied this question.