In mosquitoes, digestion involves the foregut (including the crop), midgut, and hindgut, with the midgut and crop playing important roles in processing sugar and blood meals. The well-studied midgut is a known major pathogen entry point; however, the less-explored crop may affect vector fitness and immunity. This review provides an overview of the anatomy and function of the crop, before drawing together the current state of knowledge of (I) the crop’s role in digestion, (II) its immune function, and (III) the importance of the crop microbiome and its potential role in mosquito fitness. After decades of chemical control, vector management must move beyond immediate disease prevention toward a global approach that considers mosquito biology and the crop’s diverse roles. This may make it a suitable target for new innovations by providing insights into detoxification mechanisms, microbiome-mediated functions, and their potential combined effects on vectorial capacity. Future research is needed to better understand crop function.
Rodriguez-Pereira et al. (2026) studied this question.