Neuromodulation of Pancreatic Lymph Nodes as a Therapy for Type 1 Diabetes: An Anatomical Study on the Presence of a Neuro-Immune Link in Human Pancreatic Lymph Nodes and Potential Sites for Electrical Stimulation

Key Points

• The study aims to explore the neuro-immune connections in pancreatic lymph nodes and their potential for treating type 1 diabetes.
• Anatomical examination of human pancreatic lymph nodes
• Identification of sympathetic nerve plexus locations
• Assessment of surgical accessibility for neuromodulation
• The presence of a sympathetic neuro-immune link was confirmed in pancreatic lymph nodes.
• The proximal CHA's nerve plexus is identified as a promising target for electrical stimulation.
• The site shows favorable conditions for safe device implantation.