What does this research mean for the field?

Cardiac involvement, detectable by cardiac magnetic resonance imaging, is present in 47% of newly diagnosed patients with idiopathic inflammatory myopathies and is closely associated with the severity of skeletal muscle involvement. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to investigate the relationship between cardiac involvement and skeletal muscle severity in newly diagnosed idiopathic inflammatory myopathy patients.

February 27, 2026Open Access

Cardiac involvement in newly diagnosed patients with idiopathic inflammatory myopathies is associated with skeletal muscle involvement

Q: What is the clinical evidence from this study?

Study design: Observational. Population: idiopathic inflammatory myopathies (IIM) (n=34). Intervention: Cardiac magnetic resonance imaging (CMR) assessment with laboratory and clinical evaluation vs. Healthy age- and gender-matched controls (n=9). Primary outcome: Presence of cardiac involvement detected by cardiac magnetic resonance imaging based on Updated Lake Louise Criteria (p=0.016, p=0.016).

Key Result

Cardiac magnetic resonance imaging detected cardiac involvement in 47% of newly diagnosed idiopathic inflammatory myopathies patients compared to 0% in healthy controls (p=0.016).

Key Points

The aim is to investigate the relationship between cardiac involvement and skeletal muscle severity in newly diagnosed idiopathic inflammatory myopathy patients.
Utilized cardiac magnetic resonance imaging for detection.
Assessed patient diagnoses of idiopathic inflammatory myopathies.
Evaluated the severity of skeletal muscle involvement.
Cardiac involvement was common at diagnosis.
There is a close correlation between cardiac involvement and the severity of skeletal muscle issues.

Study Design

Type

Observational (n=34)

Multicenter

Structured PICO

Is cardiac involvement detected by CMR associated with skeletal muscle involvement in newly diagnosed patients with idiopathic inflammatory myopathies?

Population

34 newly diagnosed patients with idiopathic inflammatory myopathies (IIM) and 9 age- and gender-matched healthy controls, median age 67, 53% female, single-center in Sweden.

Intervention

Cardiac magnetic resonance (CMR) imaging, blood analyses for skeletal muscle markers, ECG, and transthoracic echocardiography (TTE)

Comparator

9 age- and gender-matched healthy controls

Outcome

Cardiac involvement as detected by cardiac magnetic resonance imaging (based on Updated Lake Louise Criteria)surrogate

Cardiac involvement is present in nearly half of newly diagnosed IIM patients and is strongly associated with the severity of skeletal muscle involvement, highlighting the potential utility of early CMR screening in patients with severe myositis.

Main Result

Effect estimate: p=0.016

Absolute Event Rate: 47% vs 0%

p-value: p=0.016

Limitations

Small sample size of 34 patients and 9 controls limits statistical power
Single-centre study in Sweden reduces generalizability
Some patients received immunosuppressive therapy prior to CMR potentially affecting cardiac findings
Small subgroups for specific cardiac involvement types limit ability to detect associations with autoantibodies or other variables

Abstract

Cardiac involvement as detected by cardiac magnetic resonance imaging is common at time of diagnosis in patients with IIM and is closely linked to the severity of skeletal muscle involvement.

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Cite This Study

Hanna et al. (Tue,) conducted a observational in idiopathic inflammatory myopathies (IIM) (n=34). Cardiac magnetic resonance imaging (CMR) assessment with laboratory and clinical evaluation vs. Healthy age- and gender-matched controls (n=9) was evaluated on Presence of cardiac involvement detected by cardiac magnetic resonance imaging based on Updated Lake Louise Criteria (p=0.016, p=0.016). Cardiac magnetic resonance imaging detected cardiac involvement in 47% of newly diagnosed idiopathic inflammatory myopathies patients compared to 0% in healthy controls (p=0.016).

synapsesocial.com/papers/69a134b8ed1d949a99abe265 https://doi.org/https://doi.org/10.55563/clinexprheumatol/h01mjl

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