Exosomal EPHA2 transfers metastatic potential by stabilizing TGF-RI and activating the TGF-/SMAD3 signaling pathway in breast cancer

Key Points

• This research aims to explore how exosomal EPHA2 contributes to the metastatic potential of breast cancer cells.
• Analyzed the role of exosomal EPHA2 in breast cancer cell lines
• Investigated the activation of TGF-βRI
• Assessed the impact on TGF-β/SMAD3 signaling pathway
• Exosomal EPHA2 significantly stabilizes TGF-βRI
• Findings indicate enhanced metastatic potential in breast cancer cells
• Targeting the EPHA2-TGF-βRI axis shows potential as a therapeutic strategy