Higher mean platelet volume was associated with poor functional outcomes at 90 days with a mean difference of 0.50 (95% CI 0.31 to 0.70) in patients with acute ischemic stroke.
Systematic Review (n=10,979)
Yes
Does mean platelet volume (MPV) predict poor functional outcomes and mortality in adult patients with acute ischemic stroke?
Elevated mean platelet volume may serve as a readily available prognostic biomarker for worse 90-day functional outcomes and mortality in patients with acute ischemic stroke.
Effect estimate: MD 0.50 (95% CI 0.31 to 0.70)
In summary, MPV may be associated with worse 90-day functional outcomes and mortality; however, its correlation with impairment severity measured by NIHSS was weak. Further studies are needed to establish optimal cut-off values and incorporate MPV into predictive models.
Cabanillas-Lazo et al. (Wed,) conducted a systematic review in acute ischemic stroke (n=10,979). Mean platelet volume (MPV) vs. Lower MPV or normal MPV levels was evaluated on Poor functional outcome at 90 days (mRS >2) (MD 0.50, 95% CI 0.31 to 0.70). Higher mean platelet volume was associated with poor functional outcomes at 90 days with a mean difference of 0.50 (95% CI 0.31 to 0.70) in patients with acute ischemic stroke.