Design, synthesis, molecular docking, and antimicrobial evaluation of hybrid peptides incorporating unnatural amino acids with enhanced hydrophobic sidechains

Key Points

• The aim is to design and evaluate hybrid peptides that incorporate unnatural amino acids with enhanced hydrophobic properties for antimicrobial application.
• Synthesis of hybrid peptides with unnatural amino acids
• Molecular docking to predict interactions with target sites
• Evaluation of antimicrobial activity against multidrug-resistant pathogens
• Identified hybrid peptides exhibited significant antimicrobial activity
• Salient hydrophobic characteristics enhanced efficacy against resistant strains

Abstract