A Monoclonal Antibody ELISA-Based Assay for Measuring the Potency of Candidate H5 Clade 2.3.4.4b Pandemic Influenza Vaccines.

Key Points

• This study aims to evaluate an ELISA-based assay for measuring the potency of H5 clade 2.3.4.4b influenza vaccines.
• Developed an ELISA potency assay
• Tested inactivated H5 A/Astrakhan/3212/2020 vaccines
• Prepared libraries of antibody reagents for influenza subtypes
• The ELISA potency assay is suitable for vaccine potency determination
• The study emphasizes the need for mAb libraries for influenza vaccines
• Findings support the development of alternative mAb potency assays

Abstract