Polystyrene Nanoplastics Induce Pyroptosis in HepG2 Cells via the YAP1-cGAS-STING Signaling Axis.

Key Points

• The aim is to explore how polystyrene nanoplastics cause cell death in liver cells.
• Examined the effects of PS-nanoplastics on HepG2 cells.
• Investigated the involvement of the YAP1-cGAS-STING signaling pathway.
• Conducted mechanistic analyses to identify YAP1's role as a regulator.
• PS-nanoplastics significantly promote pyroptosis in HepG2 cells.
• YAP1 is identified as a central regulator in this process.
• Findings provide insights into potential liver toxicity mechanisms.