What question did this study set out to answer?

To investigate the relationship between CSF NAAG levels, neuroinflammatory markers, and cognitive function in people with HIV.

February 27, 2026AIDS0 citations

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N-acetyl-aspartyl-glutamate connects neuroinflammatory signatures to attention and working memory in people with HIV

LRLeah H Rubin ACAtiksh Chandra JAJesse Alt

Key Points

To investigate the relationship between CSF NAAG levels, neuroinflammatory markers, and cognitive function in people with HIV.
Measured cerebrospinal fluid (CSF) levels of N-acetyl-aspartyl-glutamate (NAAG).
Analyzed correlations between NAAG and inflammatory markers, including M-CSF and IL-15.
Assessed spatial attention and working memory performance in participants.
CSF NAAG levels correlate with multiple inflammatory markers related to cognition.
Increased levels of inflammatory biomarkers are associated with impaired spatial attention and working memory.

Abstract

Despite viral suppression, many people with HIV (PWH) experience persistent cognitive difficulties. We previously demonstrated that cerebrospinal fluid (CSF) N-acetyl-aspartyl-glutamate (NAAG) was associated with spatial attention and working memory. Here, we report that CSF NAAG also correlates with an inflammatory signature (M-CSF, IL-15, MCP-1, sCD40L, IL-18, MMP-9) that relates to spatial attention and working memory. These results suggest that CSF NAAG may serve as an immunomodulatory biomarker relevant to cognition in PWH.

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N-acetyl-aspartyl-glutamate connects neuroinflammatory signatures to attention and working memory in people with HIV

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